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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-1
All Species:
21.21
Human Site:
S345
Identified Species:
46.67
UniProt:
P43699
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P43699
NP_001073136.1
371
38596
S345
A
A
L
Q
G
Q
V
S
S
L
S
H
L
N
S
Chimpanzee
Pan troglodytes
XP_509911
401
41649
S375
A
A
L
Q
G
Q
V
S
S
L
S
H
L
N
S
Rhesus Macaque
Macaca mulatta
XP_001089890
371
38509
S345
A
A
L
Q
G
Q
V
S
S
L
S
H
L
N
S
Dog
Lupus familis
XP_849082
233
24205
L208
L
H
A
P
G
A
G
L
A
S
L
D
A
A
A
Cat
Felis silvestris
Mouse
Mus musculus
P50220
372
38552
S346
A
G
L
Q
G
Q
V
S
S
L
S
H
L
N
S
Rat
Rattus norvegicus
P23441
372
38536
S346
A
A
L
Q
G
Q
V
S
S
L
S
H
L
N
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
G269
N
F
M
N
F
S
V
G
D
L
N
S
V
Q
P
Frog
Xenopus laevis
P42587
196
22791
T171
F
N
P
A
T
F
P
T
G
I
P
F
S
A
Y
Zebra Danio
Brachydanio rerio
Q90481
269
30288
N244
S
L
Q
H
M
Q
Y
N
A
H
Y
S
A
A
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9NLC2
299
33058
A274
Y
P
P
N
A
A
A
A
A
A
A
A
A
A
A
Sea Urchin
Strong. purpuratus
NP_999800
411
44821
S374
A
S
L
H
H
Q
A
S
A
M
H
S
L
Y
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.7
99.1
40.7
N.A.
98.1
98.6
N.A.
N.A.
32
30.7
32.6
N.A.
N.A.
N.A.
26.6
38.4
Protein Similarity:
100
91.7
99.1
46.6
N.A.
98.1
98.6
N.A.
N.A.
43.4
40.4
43.4
N.A.
N.A.
N.A.
40.4
50.3
P-Site Identity:
100
100
100
6.6
N.A.
93.3
100
N.A.
N.A.
13.3
0
6.6
N.A.
N.A.
N.A.
0
40
P-Site Similarity:
100
100
100
20
N.A.
93.3
100
N.A.
N.A.
33.3
13.3
33.3
N.A.
N.A.
N.A.
26.6
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
55
37
10
10
10
19
19
10
37
10
10
10
28
37
19
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
10
0
0
10
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
10
10
0
0
10
10
0
0
0
0
0
10
0
0
0
% F
% Gly:
0
10
0
0
55
0
10
10
10
0
0
0
0
0
0
% G
% His:
0
10
0
19
10
0
0
0
0
10
10
46
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
10
10
55
0
0
0
0
10
0
55
10
0
55
0
0
% L
% Met:
0
0
10
0
10
0
0
0
0
10
0
0
0
0
0
% M
% Asn:
10
10
0
19
0
0
0
10
0
0
10
0
0
46
0
% N
% Pro:
0
10
19
10
0
0
10
0
0
0
10
0
0
0
10
% P
% Gln:
0
0
10
46
0
64
0
0
0
0
0
0
0
10
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
10
10
0
0
0
10
0
55
46
10
46
28
10
0
55
% S
% Thr:
0
0
0
0
10
0
0
10
0
0
0
0
0
0
10
% T
% Val:
0
0
0
0
0
0
55
0
0
0
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
10
0
0
0
10
0
0
10
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _